Prospective blinded study of somatic mutation detection in cell-free DNA utilizing a targeted 54-gene next generation sequencing panel in metastatic solid tumor patients

Sequencing of the mutant allele fraction of circulating cell-free DNA (cfDNA) derived from tumors is increasingly utilized to detect actionable genomic alterations in cancer. We conducted a prospective blinded study of a comprehensive cfDNA sequencing panel with 54 cancer genes. To evaluate the conc...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Kim, Seung Tae, Lee, Won Suk, Lanman, Richard B., Mortimer, Stefanie, Zill, Oliver A., Kim, Kyoung-Mee, Jang, Kee Taek, Kim, Seok-Hyung, Park, Se Hoon, Park, Joon Oh, Park, Young Suk, Lim, Ho Yeong, Eltoukhy, Helmy, Kang, Won Ki, Lee, Woo Yong, Kim, Hee-Cheol, Park, Keunchil, Lee, Jeeyun, Talasaz, AmirAli
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2015
Schlagworte:
Clinical Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4741900/
https://ncbi.nlm.nih.gov/pubmed/26452027
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