Sex-dependent effects of developmental arsenic exposure on methylation capacity and methylation regulation of the glucocorticoid receptor system in the embryonic mouse brain

Previously we have shown that prenatal moderate arsenic exposure (50 ppb) disrupts glucocorticoid receptor (GR) programming and that these changes continue into adolescence in males. However, it was not clear what the molecular mechanisms were promoting these GR programming changes or if these chang...

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Pubblicato in:Toxicol Rep
Autori principali: Allan, Andrea M., Hafez, Alexander K., Labrecque, Matthew T., Solomon, Elizabeth R., Shaikh, M. Nabil, Zheng, Xianyun, Ali, Abdulmehdi
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4741109/
https://ncbi.nlm.nih.gov/pubmed/26855884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.toxrep.2015.10.003
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