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A single mutation in helix 8 enhances the angiotensin II type 1a receptor transport and signaling
The amphipathic helix 8 in the membrane-proximal C-terminus is a structurally conserved feature of class A seven transmembrane-spanning G protein-coupled receptors (GPCRs). Mutations of this helical motif often cause receptor misfolding, defective cell surface transport and dysfunction. Surprisingly...
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| Pubblicato in: | Cell Signal |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4739548/ https://ncbi.nlm.nih.gov/pubmed/26342563 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2015.08.020 |
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