Conformational dynamics is key to understanding loss-of-function of NQO1 cancer-associated polymorphisms and its correction by pharmacological ligands

Protein dynamics is essential to understand protein function and stability, even though is rarely investigated as the origin of loss-of-function due to genetic variations. Here, we use biochemical, biophysical, cell and computational biology tools to study two loss-of-function and cancer-associated...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Medina-Carmona, Encarnación, Palomino-Morales, Rogelio J., Fuchs, Julian E., Padín-Gonzalez, Esperanza, Mesa-Torres, Noel, Salido, Eduardo, Timson, David J., Pey, Angel L.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4738246/
https://ncbi.nlm.nih.gov/pubmed/26838129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep20331
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