Precise assembly of complex beta sheet topologies from de novo designed building blocks

Design of complex alpha-beta protein topologies poses a challenge because of the large number of alternative packing arrangements. A similar challenge presumably limited the emergence of large and complex protein topologies in evolution. Here, we demonstrate that protein topologies with six and seve...

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Vydáno v:eLife
Hlavní autoři: King, Indigo Chris, Gleixner, James, Doyle, Lindsey, Kuzin, Alexandre, Hunt, John F, Xiao, Rong, Montelione, Gaetano T, Stoddard, Barry L, DiMaio, Frank, Baker, David
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2015
Témata:
Biophysics and Structural Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4737653/
https://ncbi.nlm.nih.gov/pubmed/26650357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.11012
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