Elevated glucose and oligomeric β-amyloid disrupt synapses via a common pathway of aberrant protein S-nitrosylation

Metabolic syndrome (MetS) and Type 2 diabetes mellitus (T2DM) increase risk for Alzheimer's disease (AD). The molecular mechanism for this association remains poorly defined. Here we report in human and rodent tissues that elevated glucose, as found in MetS/T2DM, and oligomeric β-amyloid (Aβ) p...

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Pubblicato in:Nat Commun
Autori principali: Akhtar, Mohd Waseem, Sanz-Blasco, Sara, Dolatabadi, Nima, Parker, James, Chon, Kevin, Lee, Michelle S., Soussou, Walid, McKercher, Scott R., Ambasudhan, Rajesh, Nakamura, Tomohiro, Lipton, Stuart A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4729876/
https://ncbi.nlm.nih.gov/pubmed/26743041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10242
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