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The Winding Pathway to Erythropoietin Along the Chemistry–Biology Frontier: A Success At Last

The total synthesis of a homogeneous erythropoietin, possessing the native amino acid sequence and chitobiose glycans at each of the three wild-type sites of N-glycosylation, has been accomplished in our laboratory. We provide herein an account of our decade-long research effort en route to this for...

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發表在:Angew Chem Int Ed Engl
Main Authors: Wilson, Rebecca M., Dong, Suwei, Wang, Ping, Danishefsky, Samuel J.
格式: Artigo
語言:Inglês
出版: 2013
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4729195/
https://ncbi.nlm.nih.gov/pubmed/23775885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201301666
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