Squalene epoxidase is a bona fide oncogene by amplification with clinical relevance in breast cancer

SQLE encodes squalene epoxidase, a key enzyme in cholesterol synthesis. SQLE has sporadically been reported among copy-number driven transcripts in multi-omics cancer projects. Yet, its functional relevance has never been subjected to systematic analyses. Here, we assessed the correlation of SQLE co...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Brown, David N., Caffa, Irene, Cirmena, Gabriella, Piras, Daniela, Garuti, Anna, Gallo, Maurizio, Alberti, Saverio, Nencioni, Alessio, Ballestrero, Alberto, Zoppoli, Gabriele
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4726025/
https://ncbi.nlm.nih.gov/pubmed/26777065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep19435
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