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Peptide Backbone Composition and Protease Susceptibility: Impact of Modification Type, Position, and Tandem Substitution
The clinical utility of peptides is limited by their rapid degradation by endogenous proteases. Modification of the peptide backbone can generate functional analogues with enhanced proteolytic stability. Existing principles for the design of such oligomers have focused primarily on effective structu...
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| Veröffentlicht in: | Chembiochem |
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| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4721950/ https://ncbi.nlm.nih.gov/pubmed/26205791 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201500312 |
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