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Fine-tuning citrate synthase flux potentiates and refines metabolic innovation in the Lenski evolution experiment

Evolutionary innovations that enable organisms to colonize new ecological niches are rare compared to gradual evolutionary changes in existing traits. We discovered that key mutations in the gltA gene, which encodes citrate synthase (CS), occurred both before and after Escherichia coli gained the ab...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Quandt, Erik M, Gollihar, Jimmy, Blount, Zachary D, Ellington, Andrew D, Georgiou, George, Barrick, Jeffrey E
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4718724/
https://ncbi.nlm.nih.gov/pubmed/26465114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.09696
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