Coupling high-throughput genetics with phylogenetic information reveals an epistatic interaction on the influenza A virus M segment

BACKGROUND: Epistasis is one of the central themes in viral evolution due to its importance in drug resistance, immune escape, and interspecies transmission. However, there is a lack of experimental approach to systematically probe for epistatic residues. RESULTS: By utilizing the information from n...

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Dades bibliogràfiques
Publicat a:BMC Genomics
Autors principals: Wu, Nicholas C., Du, Yushen, Le, Shuai, Young, Arthur P., Zhang, Tian-Hao, Wang, Yuanyuan, Zhou, Jian, Yoshizawa, Janice M., Dong, Ling, Li, Xinmin, Wu, Ting-Ting, Sun, Ren
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2016
Matèries:
Methodology Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4710013/
https://ncbi.nlm.nih.gov/pubmed/26754751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12864-015-2358-7
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