Neutrophils Oppose Uterine Epithelial Carcinogenesis via Debridement of Hypoxic Tumor Cells

Polymorphonuclear neutrophils (PMNs) are largely considered to foster cancer development despite wielding an arsenal of cytotoxic agents. Using a mouse model of PTEN-deficient uterine cancer, we describe a surprising inhibitory role for PMNs in epithelial carcinogenesis. By inducing tumor cell detac...

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Udgivet i:Cancer Cell
Main Authors: Blaisdell, Adam, Crequer, Amandine, Columbus, Devin, Daikoku, Takiko, Mittal, Khush, Dey, Sudhansu K., Erlebacher, Adrian
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4698345/
https://ncbi.nlm.nih.gov/pubmed/26678340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2015.11.005
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