Origin-Dependent Inverted-Repeat Amplification: Tests of a Model for Inverted DNA Amplification

DNA replication errors are a major driver of evolution—from single nucleotide polymorphisms to large-scale copy number variations (CNVs). Here we test a specific replication-based model to explain the generation of interstitial, inverted triplications. While no genetic information is lost, the novel...

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Veröffentlicht in:PLoS Genet
Hauptverfasser: Brewer, Bonita J., Payen, Celia, Di Rienzi, Sara C., Higgins, Megan M., Ong, Giang, Dunham, Maitreya J., Raghuraman, M. K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2015
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4689423/
https://ncbi.nlm.nih.gov/pubmed/26700858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005699
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