EglN2 associates with the NRF1‐PGC1α complex and controls mitochondrial function in breast cancer

The EglN2/PHD1 prolyl hydroxylase is an important oxygen sensor contributing to breast tumorigenesis. Emerging studies suggest that there is functional cross talk between oxygen sensing and mitochondrial function, both of which play an essential role for sustained tumor growth. However, the potentia...

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Veröffentlicht in:EMBO J
Hauptverfasser: Zhang, Jing, Wang, Chengyang, Chen, Xi, Takada, Mamoru, Fan, Cheng, Zheng, Xingnan, Wen, Haitao, Liu, Yong, Wang, Chenguang, Pestell, Richard G, Aird, Katherine M, Kaelin, William G, Liu, Xiaole Shirley, Zhang, Qing
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2015
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4687683/
https://ncbi.nlm.nih.gov/pubmed/26492917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201591437
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