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HSV targeting of the host phosphatase PP1α is required for disseminated disease in the neonate and contributes to pathogenesis in the brain

Newborns are significantly more susceptible to severe disease after infection with herpes simplex virus (HSV) compared with adults, with differences in the host response implicated as a major factor. To understand host response differences between these age groups, we investigated the shutoff of pro...

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Bibliografische gegevens
Gepubliceerd in:Proc Natl Acad Sci U S A
Hoofdauteurs: Wilcox, Douglas R., Muller, William J., Longnecker, Richard
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2015
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4687582/
https://ncbi.nlm.nih.gov/pubmed/26621722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1513045112
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