Chemically induced DNA hypomethylation in breast carcinoma cells detected by the amplification of intermethylated sites

INTRODUCTION: Compromised patterns of gene expression result in genomic instability, altered patterns of gene expression and tumour formation. Specifically, aberrant DNA hypermethylation in gene promoter regions leads to gene silencing, whereas global hypomethylation events can result in chromosomal...

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Hlavní autoři: Sadikovic, Bekim, Haines, Thomas R, Butcher, Darci T, Rodenhiser, David I
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2004
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC468641/
https://ncbi.nlm.nih.gov/pubmed/15217500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr799
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