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Population pharmacokinetics of unbound hydrocortisone in critically ill neonates and infants with vasopressor-resistant hypotension

OBJECTIVE: To determine the population pharmacokinetics of unbound hydrocortisone (HC) in critically ill neonates and infants receiving intravenous HC for treatment of vasopressor-resistant hypotension and to identify patient-specific sources of pharmacokinetic variability. DESIGN: Prospective obser...

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Publicado en:Pediatr Crit Care Med
Autores principales: Vezina, Heather E., Ng, Chee M., Vazquez, Delia M., Barks, John D., Bhatt-Mehta, Varsha
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4682874/
https://ncbi.nlm.nih.gov/pubmed/24797719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/PCC.0000000000000152
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