The effect of androgens on ovarian follicle maturation: Dihydrotestosterone suppress FSH-stimulated granulosa cell proliferation by upregulating PPARγ-dependent PTEN expression.

Intraovarian hyperandrogenism is one of the determining factors of follicular arrest in women with polycystic ovary syndrome (PCOS). Using androgenized rat models, we investigated the effects of androgens on metabolism, as well as on factors involved in follicular arrest and the reduced number of es...

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Publicat a:Sci Rep
Autors principals: Chen, Mei-Jou, Chou, Chia-Hung, Chen, Shee-Uan, Yang, Wei-Shiung, Yang, Yu-Shih, Ho, Hong-Nerng
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4682139/
https://ncbi.nlm.nih.gov/pubmed/26674985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep18319
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