Comparison of the Structure and Activity of Glycosylated and Aglycosylated Human Carboxylesterase 1

Human Carboxylesterase 1 (hCES1) is the key liver microsomal enzyme responsible for detoxification and metabolism of a variety of clinical drugs. To analyse the role of the single N-linked glycan on the structure and activity of the enzyme, authentically glycosylated and aglycosylated hCES1, generat...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Arena de Souza, Victoria, Scott, David J., Nettleship, Joanne E., Rahman, Nahid, Charlton, Michael H., Walsh, Martin A., Owens, Raymond J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4676782/
https://ncbi.nlm.nih.gov/pubmed/26657071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0143919
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