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Asymmetric protonation of EmrE
The small multidrug resistance transporter EmrE is a homodimer that uses energy provided by the proton motive force to drive the efflux of drug substrates. The pKa values of its “active-site” residues—glutamate 14 (Glu14) from each subunit—must be poised around physiological pH values to efficiently...
Guardat en:
| Publicat a: | J Gen Physiol |
|---|---|
| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
The Rockefeller University Press
2015
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4664823/ https://ncbi.nlm.nih.gov/pubmed/26573622 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201511404 |
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