2,3-Oxidosqualene cyclase protects liver cells from the injury of intermittent hypoxia by regulating lipid metabolism

PURPOSE: 2,3-Oxidosqualene cyclase (OSC), an important enzyme of cholesterol biosynthesis, catalyzes the highly selective cyclization of 2,3-monoepoxysqualene to lanosterol. Intermittent hypoxia (IH) is a hallmark feature in obstructive sleep apnea (OSA) which is increasingly recognized as an indepe...

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Bibliographic Details
Published in:Sleep Breath
Main Authors: Zhen, Yue-qiao, Wu, Yu-min, Sang, Yan-hong, Wang, Yan, Song, Qiu-yan, Yu, Ling, Rao, Xiao-juan, Dong, Rui-hong
Format: Artigo
Language:Inglês
Published: Springer Berlin Heidelberg 2015
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4662960/
https://ncbi.nlm.nih.gov/pubmed/25855471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11325-015-1167-1
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