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Asymmetric Synthesis of β-Amino Amides by Catalytic Enantioconvergent 2-Aza-Cope Rearrangement

Dynamic kinetic resolutions of α-stereogenic-β-formyl amides in asymmetric 2-aza-Cope rearrangements are described. Chiral phosphoric acids catalyze this rare example of a non-hydrogenative DKR of a β-oxo acid derivative. The [3,3]-rearrangement occurs with high diastereo- and enantiocontrol, formin...

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Bibliografiske detaljer
Udgivet i:J Am Chem Soc
Main Authors: Goodman, C. Guy, Johnson, Jeffrey S.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4661081/
https://ncbi.nlm.nih.gov/pubmed/26561873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b09593
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