Macrophage skewing by Phd2 haplodeficiency prevents ischaemia by inducing arteriogenesis

PHD2 serves as an oxygen sensor that rescues blood supply by regulating vessel formation and shape in case of oxygen shortage(1–5). However, it is unknown whether PHD2 can influence arteriogenesis. Here we studied the role of PHD2 in collateral artery growth by using hindlimb ischaemia as a model, a...

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Publicat a:Nature
Autors principals: Takeda, Yukiji, Costa, Sandra, Delamarre, Estelle, Roncal, Carmen, de Oliveira, Rodrigo Leite, Squadrito, Mario Leonardo, Finisguerra, Veronica, Deschoemaeker, Sofie, Bruyére, Françoise, Wenes, Mathias, Hamm, Alexander, Serneels, Jens, Magat, Julie, Bhattacharyya, Tapan, Anisimov, Andrey, Jordan, Benedicte F., Alitalo, Kari, Maxwell, Patrick, Gallez, Bernard, Zhuang, Zhen W., Saito, Yoshihiko, Simons, Michael, De Palma, Michele, Mazzone, Massimiliano
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4659699/
https://ncbi.nlm.nih.gov/pubmed/21983962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature10507
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