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Long range Trp-Trp interaction initiates the folding pathway of a pro-angiogenic β-hairpin peptide
HPLW, a designed VEGF (Vascular Endothelium Growth Factor) receptor-binding peptide, assumes a well folded β-hairpin conformation in water and is able to induce angiogenesis in vivo. In this study, we investigated at atomic resolution the thermal folding/unfolding pathway of HPLW by means of an orig...
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| Publicat a: | Sci Rep |
|---|---|
| Autors principals: | , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group
2015
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4658480/ https://ncbi.nlm.nih.gov/pubmed/26602442 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep16651 |
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