SphK1 mediates hepatic inflammation in a mouse model of NASH induced by high saturated fat feeding and initiates proinflammatory signaling in hepatocytes

Steatohepatitis occurs in up to 20% of patients with fatty liver disease and leads to its primary disease outcomes, including fibrosis, cirrhosis, and increased risk of hepatocellular carcinoma. Mechanisms that mediate this inflammation are of major interest. We previously showed that overload of sa...

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Detalhes bibliográficos
Publicado no:J Lipid Res
Main Authors: Geng, Tuoyu, Sutter, Alton, Harland, Michael D., Law, Brittany A., Ross, Jessica S., Lewin, David, Palanisamy, Arun, Russo, Sarah B., Chavin, Kenneth D., Cowart, L. Ashley
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4655991/
https://ncbi.nlm.nih.gov/pubmed/26482537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M063511
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