Essential Role of GATA2 in the Negative Regulation of Type 2 Deiodinase Gene by Liganded Thyroid Hormone Receptor β2 in Thyrotroph

The inhibition of thyrotropin (thyroid stimulating hormone; TSH) by thyroid hormone (T3) and its receptor (TR) is the central mechanism of the hypothalamus-pituitary-thyroid axis. Two transcription factors, GATA2 and Pit-1, determine thyrotroph differentiation and maintain the expression of the β su...

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Bibliographic Details
Published in:PLoS One
Main Authors: Matsunaga, Hideyuki, Sasaki, Shigekazu, Suzuki, Shingo, Matsushita, Akio, Nakamura, Hirotoshi, Nakamura, Hiroko Misawa, Hirahara, Naoko, Kuroda, Go, Iwaki, Hiroyuki, Ohba, Kenji, Morita, Hiroshi, Oki, Yutaka, Suda, Takafumi
Format: Artigo
Language:Inglês
Published: Public Library of Science 2015
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4646574/
https://ncbi.nlm.nih.gov/pubmed/26571013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0142400
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