Recruitment of β-Arrestin 1 and 2 to the β(2)-Adrenoceptor: Analysis of 65 Ligands

Beyond canonical signaling via G(α)s and cAMP, the concept of functional selectivity at β(2)-adrenoceptors (β(2)ARs) describes the ability of adrenergic drugs to stabilize ligand-specific receptor conformations to initiate further signaling cascades comprising additional G-protein classes or β-arres...

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Vydáno v:J Pharmacol Exp Ther
Hlavní autoři: Littmann, Timo, Göttle, Martin, Reinartz, Michael T., Kälble, Solveig, Wainer, Irving W., Ozawa, Takeaki, Seifert, Roland
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Pharmacology and Experimental Therapeutics 2015
Témata:
Cellular and Molecular
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4631950/
https://ncbi.nlm.nih.gov/pubmed/26306764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.115.227959
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