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Effects of cathepsin K deficiency on intercellular junction proteins, luminal mucus layers, and extracellular matrix constituents in the mouse colon

Cathepsin K has been shown to exhibit antimicrobial and anti-inflammatory activities in the mouse colon. To further elucidate its role, we used Ctsk(−/−) mice and demonstrated that the absence of cathepsin K was accompanied by elevated protein levels of related cysteine cathepsins (cathepsins B, L,...

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Bibliographic Details
Published in:Biol Chem
Main Authors: Arampatzidou, Maria, Schütte, André, Hansson, Gunnar C., Saftig, Paul, Brix, Klaudia
Format: Artigo
Language:Inglês
Published: 2012
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4631841/
https://ncbi.nlm.nih.gov/pubmed/23152408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1515/hsz-2012-0204
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