Failure to upregulate cell surface PD-1 is associated with dysregulated stimulation of T cells by TGN1412-like CD28 superagonist

The CD28 superagonist (CD28SA) TGN1412 was administered to humans as an agent that can selectively activate and expand regulatory T cells but resulted in uncontrolled T cell activation accompanied by cytokine storm. The molecular mechanisms that underlie this uncontrolled T cell activation are uncle...

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Main Authors: Thaventhiran, Thilipan, Alhumeed, Naif, Yeang, Han XA, Sethu, Swaminathan, Downey, Jocelyn S, Alghanem, Ahmad F, Olayanju, Adedamola, Smith, Emma L, Cross, Michael J, Webb, Steven D, Williams, Dominic P, Bristow, Adrian, Ball, Christina, Stebbings, Richard, Sathish, Jean G
Formáid: Artigo
Teanga:Inglês
Foilsithe: Taylor & Francis 2014
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Reports
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4622985/
https://ncbi.nlm.nih.gov/pubmed/25517314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.29758
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