Failure to upregulate cell surface PD-1 is associated with dysregulated stimulation of T cells by TGN1412-like CD28 superagonist

The CD28 superagonist (CD28SA) TGN1412 was administered to humans as an agent that can selectively activate and expand regulatory T cells but resulted in uncontrolled T cell activation accompanied by cytokine storm. The molecular mechanisms that underlie this uncontrolled T cell activation are uncle...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:MAbs
Auteurs principaux: Thaventhiran, Thilipan, Alhumeed, Naif, Yeang, Han XA, Sethu, Swaminathan, Downey, Jocelyn S, Alghanem, Ahmad F, Olayanju, Adedamola, Smith, Emma L, Cross, Michael J, Webb, Steven D, Williams, Dominic P, Bristow, Adrian, Ball, Christina, Stebbings, Richard, Sathish, Jean G
Format: Artigo
Langue:Inglês
Publié: Taylor & Francis 2014
Sujets:
Reports
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4622985/
https://ncbi.nlm.nih.gov/pubmed/25517314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.29758
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires