Phage display-based generation of novel internalizing antibody fragments for immunotoxin-based treatment of acute myeloid leukemia

The current standard treatment for acute myeloid leukemia (AML) is chemotherapy based on cytarabine and daunorubicine (7 + 3), but it discriminates poorly between malignant and benign cells. Dose-limiting off‑target effects and intrinsic drug resistance result in the inefficient eradication of leuke...

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Detalhes bibliográficos
Publicado no:MAbs
Main Authors: Fitting, Jenny, Blume, Tobias, ten Haaf, Andre, Blau, Wolfgang, Gattenlöhner, Stefan, Tur, Mehmet Kemal, Barth, Stefan
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2015
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Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4622674/
https://ncbi.nlm.nih.gov/pubmed/25760770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2015.1007818
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