Effect of IL-7 therapy on naïve and memory T cell homeostasis in aged rhesus macaques

Aging is associated with gradual deterioration of adaptive immune function, a hallmark of which is the profound loss of naïve T cells (T(N)) associated with decline in thymic output and export of new cells into the peripheral T cell pool. Since the lymphotropic cytokine IL-7 plays crucial roles in b...

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Publicat a:J Immunol
Autors principals: Okoye, Afam A., Rohankhedkar, Mukta, Konfe, Audrie L., Abana, Chike O., Reyes, Matthew D., Clock, Joseph A., Duell, Derick M., Sylwester, Andrew W., Sammader, Partha, Legasse, Alfred W., Park, Byung S., Axthelm, Michael K., Nikolich-Žugich, Janko, Picker, Louis J.
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4617185/
https://ncbi.nlm.nih.gov/pubmed/26416281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1500609
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