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Investigating dynamic interdomain allostery in Pin1

Signaling proteins often sequester complementary functional sites in separate domains. How do the different domains communicate with one another? An attractive system to address this question is the mitotic regulator, human Pin1 (Lu et al., Nature 380:544–547, 1996). Pin-1 consists of two mutually t...

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Bibliographic Details
Published in:Biophys Rev
Main Author: Peng, Jeffrey W.
Format: Artigo
Language:Inglês
Published: Springer Berlin Heidelberg 2015
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4610412/
https://ncbi.nlm.nih.gov/pubmed/26495045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12551-015-0171-9
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