ARID1A loss correlates with mismatch repair deficiency and intact p53 expression in high-grade endometrial carcinomas

BAF250a (ARID1A) loss is a frequent event in high-grade endometrial cancers. It has been proposed that ARID1A is a driver gene, with ARID1A mutations occurring secondary to deregulated mismatch repair mechanism in gastric cancers, representing an alternative oncogenic pathway to p53 alteration. The...

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Publicat a:Mod Pathol
Autors principals: Allo, Ghassan, Bernardini, Marcus Q, Wu, Ren-Chin, Shih, Ie-Ming, Kalloger, Steve, Pollett, Aaron, Gilks, C Blake, Clarke, Blaise A
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4603563/
https://ncbi.nlm.nih.gov/pubmed/23887303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/modpathol.2013.144
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