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Combining genomic and network characteristics for extended capability in predicting synergistic drugs for cancer
The identification of synergistic chemotherapeutic agents from a large pool of candidates is highly challenging. Here, we present a Ranking-system of Anti-Cancer Synergy (RACS) that combines features of targeting networks and transcriptomic profiles, and validate it on three types of cancer. Using d...
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| Опубликовано в: : | Nat Commun |
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| Главные авторы: | , , , , , , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Nature Pub. Group
2015
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4598846/ https://ncbi.nlm.nih.gov/pubmed/26412466 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9481 |
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