CD47 Blockade Triggers T cell-mediated Destruction of Immunogenic Tumors

Macrophage phagocytosis of tumor cells mediated by CD47-specific blocking antibodies has been proposed to be the major effector mechanism in xenograft models. Using syngeneic immunocompetent tumor models, we reveal that in the therapeutic effects of CD47 blockade depend on dendritic cell (DC) but no...

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Bibliografske podrobnosti
izdano v:Nat Med
Main Authors: Liu, Xiaojuan, Pu, Yang, Cron, Kyle, Deng, Liufu, Kline, Justin, Frazier, William A., Xu, Hairong, Peng, Hua, Fu, Yang-Xin, Xu, Meng Michelle
Format: Artigo
Jezik:Inglês
Izdano: 2015
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4598283/
https://ncbi.nlm.nih.gov/pubmed/26322579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3931
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