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CD47 Blockade Triggers T cell-mediated Destruction of Immunogenic Tumors
Macrophage phagocytosis of tumor cells mediated by CD47-specific blocking antibodies has been proposed to be the major effector mechanism in xenograft models. Using syngeneic immunocompetent tumor models, we reveal that in the therapeutic effects of CD47 blockade depend on dendritic cell (DC) but no...
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| Publié dans: | Nat Med |
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| Auteurs principaux: | , , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4598283/ https://ncbi.nlm.nih.gov/pubmed/26322579 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3931 |
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