Systemic Retinaldehyde Treatment Corrects Retinal Oxidative Stress, Rod Dysfunction, and Impaired Visual Performance in Diabetic Mice

PURPOSE: Diabetes appears to induce a visual cycle defect because rod dysfunction is correctable with systemic treatment of the visual cycle chromophore 11-cis-retinaldehyde. However, later studies have found no evidence for visual cycle impairment. Here, we further examined whether photoreceptor dy...

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Udgivet i:Invest Ophthalmol Vis Sci
Main Authors: Berkowitz, Bruce A., Kern, Timothy S., Bissig, David, Patel, Priya, Bhatia, Ankit, Kefalov, Vladimir J., Roberts, Robin
Format: Artigo
Sprog:Inglês
Udgivet: The Association for Research in Vision and Ophthalmology 2015
Fag:
Retinal Cell Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4594469/
https://ncbi.nlm.nih.gov/pubmed/26431483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.15-16990
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