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Complexity of the human memory B-cell compartment is determined by the versatility of clonal diversification in germinal centers

Our knowledge about the clonal composition and intraclonal diversity of the human memory B-cell compartment and the relationship between memory B-cell subsets is still limited, although these are central issues for our understanding of adaptive immunity. We performed a deep sequencing analysis of re...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Budeus, Bettina, Schweigle de Reynoso, Stefanie, Przekopowitz, Martina, Hoffmann, Daniel, Seifert, Marc, Küppers, Ralf
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4586852/
https://ncbi.nlm.nih.gov/pubmed/26324941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1511270112
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