A whole-cell tumor vaccine modified to express fibroblast activation protein induces antitumor immunity against both tumor cells and cancer-associated fibroblasts

Cancer-associated fibroblasts (CAFs) are common components of the tumor-suppressive microenvironment, and are a major determinant of the poor outcome of therapeutic vaccination. In this study, we modified tumor cells to express the fibroblast activation protein (FAP), which is highly expressed by CA...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Chen, Meihua, Xiang, Rong, Wen, Yuan, Xu, Guangchao, Wang, Chunting, Luo, Shuntao, Yin, Tao, Wei, Xiawei, Shao, Bin, Liu, Ning, Guo, Fuchun, Li, Meng, Zhang, Shuang, Li, Minmin, Ren, Kexing, Wang, Yongsheng, Wei, Yuquan
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4585784/
https://ncbi.nlm.nih.gov/pubmed/26394925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep14421
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