A synthetic consensus anti–spike protein DNA vaccine induces protective immunity against Middle East respiratory syndrome coronavirus in nonhuman primates

First identified in 2012, Middle East respiratory syndrome (MERS) is caused by an emerging human coronavirus, which is distinct from the severe acute respiratory syndrome coronavirus (SARS-CoV), and represents a novel member of the lineage C betacoronoviruses. Since its identification, MERS coronavi...

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Publicado no:Sci Transl Med
Main Authors: Muthumani, Karuppiah, Falzarano, Darryl, Reuschel, Emma L., Tingey, Colleen, Flingai, Seleeke, Villarreal, Daniel O., Wise, Megan, Patel, Ami, Izmirly, Abdullah, Aljuaid, Abdulelah, Seliga, Alecia M., Soule, Geoff, Morrow, Matthew, Kraynyak, Kimberly A., Khan, Amir S., Scott, Dana P., Feldmann, Friederike, LaCasse, Rachel, Meade-White, Kimberly, Okumura, Atsushi, Ugen, Kenneth E., Sardesai, Niranjan Y., Kim, J. Joseph, Kobinger, Gary, Feldmann, Heinz, Weiner, David B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4573558/
https://ncbi.nlm.nih.gov/pubmed/26290414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aac7462
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