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Impact of cysteine variants on the structure, activity, and stability of recombinant human α-galactosidase A
Recombinant human α-galactosidase A (rhαGal) is a homodimeric glycoprotein deficient in Fabry disease, a lysosomal storage disorder. In this study, each cysteine residue in rhαGal was replaced with serine to understand the role each cysteine plays in the enzyme structure, function, and stability. Co...
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| Yayımlandı: | Protein Sci |
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| Asıl Yazarlar: | , , , , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
John Wiley & Sons, Ltd
2015
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4570535/ https://ncbi.nlm.nih.gov/pubmed/26044846 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2719 |
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