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Impact of cysteine variants on the structure, activity, and stability of recombinant human α-galactosidase A

Recombinant human α-galactosidase A (rhαGal) is a homodimeric glycoprotein deficient in Fabry disease, a lysosomal storage disorder. In this study, each cysteine residue in rhαGal was replaced with serine to understand the role each cysteine plays in the enzyme structure, function, and stability. Co...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Protein Sci
मुख्य लेखकों: Qiu, Huawei, Honey, Denise M, Kingsbury, Jonathan S, Park, Anna, Boudanova, Ekaterina, Wei, Ronnie R, Pan, Clark Q, Edmunds, Tim
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: John Wiley & Sons, Ltd 2015
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC4570535/
https://ncbi.nlm.nih.gov/pubmed/26044846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2719
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