Impact of cysteine variants on the structure, activity, and stability of recombinant human α-galactosidase A

Recombinant human α-galactosidase A (rhαGal) is a homodimeric glycoprotein deficient in Fabry disease, a lysosomal storage disorder. In this study, each cysteine residue in rhαGal was replaced with serine to understand the role each cysteine plays in the enzyme structure, function, and stability. Co...

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Bibliographic Details
Published in:Protein Sci
Main Authors: Qiu, Huawei, Honey, Denise M, Kingsbury, Jonathan S, Park, Anna, Boudanova, Ekaterina, Wei, Ronnie R, Pan, Clark Q, Edmunds, Tim
Format: Artigo
Language:Inglês
Published: John Wiley & Sons, Ltd 2015
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4570535/
https://ncbi.nlm.nih.gov/pubmed/26044846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2719
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