Steering Evolution with Sequential Therapy to Prevent the Emergence of Bacterial Antibiotic Resistance

The increasing rate of antibiotic resistance and slowing discovery of novel antibiotic treatments presents a growing threat to public health. Here, we consider a simple model of evolution in asexually reproducing populations which considers adaptation as a biased random walk on a fitness landscape....

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Bibliografische gegevens
Gepubliceerd in:PLoS Comput Biol
Hoofdauteurs: Nichol, Daniel, Jeavons, Peter, Fletcher, Alexander G., Bonomo, Robert A., Maini, Philip K., Paul, Jerome L., Gatenby, Robert A., Anderson, Alexander R.A., Scott, Jacob G.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2015
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4567305/
https://ncbi.nlm.nih.gov/pubmed/26360300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1004493
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