Erk negative feedback control enables pre-B cell transformation and represents a therapeutic target in acute lymphoblastic leukemia

Studying mechanisms of malignant transformation of human pre-B cells, we found that acute activation of oncogenes induced immediate cell death in the vast majority of cells. Few surviving pre-B cell clones had acquired permissiveness to oncogenic signaling by strong activation of negative feedback r...

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Pubblicato in:Cancer Cell
Autori principali: Shojaee, Seyedmehdi, Caeser, Rebecca, Buchner, Maike, Park, Eugen, Swaminathan, Srividya, Hurtz, Christian, Geng, Huimin, Chan, Lai N, Klemm, Lars, Hofmann, Wolf-Karsten, Qiu, Yi Hua, Zhang, Nianxiang, Coombes, Kevin R., Paietta, Elisabeth, Molkentin, Jeffery, Koeffler, H Phillip, Willman, Cheryl L, Hunger, Stephen P., Melnick, Ari, Kornblau, Steven M., Müschen, Markus
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4565502/
https://ncbi.nlm.nih.gov/pubmed/26073130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2015.05.008
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