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Toll-like receptor 9 trafficking and signaling for type I interferons requires PIKfyve activity

Toll-like receptors (TLRs) traffic to distinct membranes for signaling. TLR7 and TLR9 recognize viral nucleic acids in the endosomes and induce robust anti-viral program. Signaling from these TLRs bifurcate at the level of distinct endosomal compartments, namely VAMP3(+) and LAMP(+) endosomes, to me...

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Detalhes bibliográficos
Publicado no:Int Immunol
Main Authors: Hayashi, Kachiko, Sasai, Miwa, Iwasaki, Akiko
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4560039/
https://ncbi.nlm.nih.gov/pubmed/25925170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/intimm/dxv021
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