YAP1 Exerts Its Transcriptional Control via TEAD-Mediated Activation of Enhancers

YAP1 is a major effector of the Hippo pathway and a well-established oncogene. Elevated YAP1 activity due to mutations in Hippo pathway components or YAP1 amplification is observed in several types of human cancers. Here we investigated its genomic binding landscape in YAP1-activated cancer cells, a...

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Pubblicato in:PLoS Genet
Autori principali: Stein, Claudia, Bardet, Anaïs Flore, Roma, Guglielmo, Bergling, Sebastian, Clay, Ieuan, Ruchti, Alexandra, Agarinis, Claudia, Schmelzle, Tobias, Bouwmeester, Tewis, Schübeler, Dirk, Bauer, Andreas
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2015
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4546604/
https://ncbi.nlm.nih.gov/pubmed/26295846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005465
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