Molecular Design of Bisphosphonate-Modified Proteins for Efficient Bone Targeting In Vivo

To establish a rational molecular design for bisphosphonate (BP)-modified proteins for efficient bone targeting, a pharmacokinetic study was performed using a series of alendronate (ALN), a nitrogen-containing BP, modified proteins with various molecular weights and varying degrees of modification....

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Udgivet i:PLoS One
Main Authors: Katsumi, Hidemasa, Sano, Jun-ichi, Nishikawa, Makiya, Hanzawa, Keiko, Sakane, Toshiyasu, Yamamoto, Akira
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4545940/
https://ncbi.nlm.nih.gov/pubmed/26287482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0135966
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