Downregulation of Poly(ADP-Ribose) Polymerase 1 by a Viral Processivity Factor Facilitates Lytic Replication of Gammaherpesvirus

In Kaposi's sarcoma-associated herpesvirus (KSHV), poly(ADP-ribose) polymerase 1 (PARP-1) acts as an inhibitor of lytic replication. Here, we demonstrate that KSHV downregulated PARP-1 upon reactivation. The viral processivity factor of KSHV (PF-8) interacted with PARP-1 and was sufficient to d...

Full description

Saved in:
Bibliographic Details
Published in:J Virol
Main Authors: Chung, Woo-Chang, Park, Joo-Hee, Kang, Hye-Ri, Song, Moon Jung
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2015
Subjects:
Genome Replication and Regulation of Viral Gene Expression
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4542354/
https://ncbi.nlm.nih.gov/pubmed/26157130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00559-15
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items